This website and underlying databases are maintained. Tragedy of the gifted rugby player, 18, who died after buying deadly fatburning pills online, the daily mail reports. Aldrich d199303 page 1 of 7 sigmaaldrich material safety data sheet version 3. Selective adsorption and efficient photodegradation of 2, 4 dinitrophenol in aqueous solution, journal of hazardous materials, vol. The chemical structure of 2, 4 dinitrophenol is shown in figure 1. Nov 16, 2012 new highly selective method is suggested for synthesis of 2, 4 dinitrophenol by nitration of phenol with nitric acid in an aqueousalcoholic medium at the boiling point of the reaction mixture. It is also used in the synthesis of coumarins and in the preparation of chloroformates as pharmaceutical reagents. Our evidencebased analysis on 2, 4 dinitrophenol features 23 unique references to scientific papers. This has been the case with 2, 4 dinitrophenol dnp, which despite abundant evidence of its. Get a printable copy pdf file of the complete article 2. Full text is available as a scanned copy of the original print version.
Incompatible with heavy metals and their compounds. Chemical properties of 2secbutyl4,6dinitrophenol cas 88857 download as pdf file download as excel file download as 2d mole file predict properties. Dnp is sold mostly over the internet under a number of different names as a weight lossslimming aid. To most americans, 2, 4d is probably just a mish mash of numbers and letters. Nevertheless, an explosion in a munitions factory at rainham in essex in 1916 was attributed to 2, 4 dinitrophenol. Files are available under licenses specified on their description page. O 2,4dinitrofenol e rapidamente adsorvido atraves do trato gastrointestinal, bem com pela pele e pulmoes. Explodes if dried and exposed to heat, flame, friction or shock. To activate carboxylic acids by converting them into dinitrophenyl dnp esters. Technical details about 2,4dinitrophenol, learn more about the structure, uses. Structure, properties, spectra, suppliers and links for. Full text full text is available as a scanned copy of the original print version. Medical knowledge, especially in toxicology, is built on experimentation and the preciously won experience over time treating the ingestions and poisonings of our patients.
Chemical properties of 2secbutyl4,6dinitrophenol cas 88. Chronic oral exposure to 2, 4 dinitrophenol in humans and animals has resulted in the formation of cataracts and skin lesions and has caused effects on the bone marrow, cns, and cardiovascular system. It is volatile with steam and is soluble in most organic solvents as well as aqueous alkaline solutions. All structured data from the file and property namespaces is available under the creative commons cc0 license.
Ignoring these hard won lessons, and having additional patients repeat the suffering is a most pitiful waste. Using 2, 4 dnp as a shell filling was less sensitive than picric acid on its own. It has a role as a bacterial xenobiotic metabolite. Dnp 2, 4 dinitrophenol is a chemical product that was historically used as an antiseptic, herbicide, and explosive. Pdf two deaths attributed to the use of 2,4dinitrophenol. The mechanism of uncoupling of oxidative phosphorylation by 2, 4dinitrophenol received for publication, january 18, 1967 gifford b. Sep 26, 2019 the atsdr toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the hazardous substance described here. Use of the information, documents and data from the echa website is subject to the terms and conditions of this legal notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the echa website may be reproduced, distributed andor used, totally or in part, for noncommercial purposes provided that echa is.
Two died within 3 h after admission, while the other 14 responded to supportive treatment and hemoperfusion. Later on in the 19 th century chemists invented tnt 2,4,6trinitrotoluene and 2,4,6trinitrophenol, picric acid, both of which were widely used as explosives in first world war shell fillings. This page is regularly updated, to include the most recently available clinical trial evidence. Search results for 2,4dinitrophenol at sigmaaldrich. New highly selective method is suggested for synthesis of 2,4dinitrophenol by nitration of phenol with nitric acid in an aqueousalcoholic medium at the boiling point. Chemical and physical properties of 2secbutyl4,6dinitrophenol. The mechanism of uncoupling of oxidative phosphorylation. To report clinical features and treatment of 16 cases of acute 2,4dinitrophenol poisoning. The mechanism of uncoupling of oxidative phosphorylation by 2. Also incompatible with strong oxidizing agents, strong bases and reducing agents. So while it goes work well at burning fat, youre ingesting an industrial poison to do so, and that is no hyperbole. We report the cases of two individuals, one in tacoma, wa, and the second in san diego, ca, whose deaths were attributed to ingestion of 2, 4 dinitrophenol 2, 4 dnp.
Links to pubmed are also available for selected references. It is a yellow, crystalline solid that has a sweet, musty odor. See working with the information on this page section below for important notes about this data. Show this safety data sheet to the doctor in attendance. Later on in the 19 th century chemists invented tnt 2, 4,6trinitrotoluene and 2, 4,6trinitrophenol, picric acid, both of which were widely used as explosives in first world war shell fillings. A weight loss agent with significant acute toxicity and risk of death, however in studies of intermediateduration oral exposure to 2,4dnp, cases of death from agranulocytosis described in the discussion of hematological effects have been attributed to. Epa rfdrfc work group and determined to be inadequate for the derivation of an inhalation rfc.
Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry. Like tnt, it was found to be toxic to the munition workers handling it. Know about technical details of 2,4dinitrophenol like. Dnp is used in developing photography, killing fungi, and as an industrial pesticide.
Dnp is known by its official name, 2,4dinitrophenol, and is considered an industrial chemical. Like t4, the drug stimulates metabolism by uncoupling oxidative phosphorylation in mitochondria. It is a substituted hydrazine, and is often used to qualitatively test for carbonyl groups associated with aldehydes and ketones. A toxic dye, chemically related to trinitrophenol picric acid, used in biochemical studies of oxidative processes where it uncouples oxidative phosphorylation. Clinical features and treatment in patients with acute 2,4. For additional information on the health effects of this chemical, interested parties are referred to the.
It uncouples oxidative phosphorylation by carrying protons across the mitochondrial membrane, leading to a rapid consumption of energy without generation of atp. Safety data sheet northwest missouri state university. Table of contents 1 history 2 how it works 3 bodybuilding 4 side effects 5. Composition and information on ingredients composition. First aid measures general advice consult a physician. A phenolate anion obtained from 2, 4 dinitrophenol. Dnp is an inhibitor of efficient energy atp production in cells with mitochondria. Once the intermediate is broken down, by other reactions, the coupling enzyme is prevented from reassociation with the electron transport particles by 2, 4 dinitrophenol. Product is supplied moist with water since the dry powder may be susceptible to. Anyway, i learned about a chemical called 2, 4 dinitrophenol or dnp, which is what they call it in bodybuilding circles.
It has a role as an oxidative phosphorylation inhibitor, a bacterial xenobiotic metabolite and an antiseptic drug. We insist the risk is on us, so simply try instant knockout for 90 days and if you do not see any results then we will gladly refund your money. It is just of one of many newspapers and websites who have reported on the death of chris mapletoft, who died after taking 2,4dinitrophenol dnp. A total of 16 patients suffering from acute poisoning due to nonoral exposure to 2,4dinitrophenol were sent to our hospital. In bodybuilding, it is used for rapid fat loss, but its considered extremely dangerous when ingested. To prepare the corresponding ester via acylation reaction using isobutyric anhydride catalyzed by hafnium triflate. The lowest published lethal human oral dose of dnp is 4. This page was last edited on 12 february 2016, at 20. It sublimes, is volatile with steam, and is soluble in most organic solvents as well as aqueous alkaline solutions. I stopped using that crap, but i was still a bit heavier than i wouldve liked, and it was winter and i was on an ankle monitor and stuck at home at the time, which made it pretty hard for me to get any exercise. Our evidencebased analysis on 2,4dinitrophenol features 23 unique references to scientific papers. But to farmers and gardeners, it is the most widely used herbicide in the world and the third most commonly used in north america. A weight loss agent with significant acute toxicity and risk of death, however in studies of intermediateduration oral exposure to 2, 4 dnp, cases of death from agranulocytosis described in the discussion of hematological effects have been attributed to. Identification name 2,4dinitrophenol accession number db04528 expt01235 type small molecule groups experimental description.
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